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Short Paper | Special issue | Vol 97, No. 1, 2018, pp.621-631
Published online, 17th April, 2018
DOI: 10.3987/COM-18-S(T)49
Concise Synthesis of (±)-Aurantioclavine

Hideo Ikota, Chihiro Tsukano,* and Yoshiji Takemoto*

*Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-machi, Sakyo-ku, Kyoto 606-8501, Japan


A synthetic route to (±)-aurantioclavine has been established using a six-step transformation without toxic metal reagents. This synthetic route is useful because it is not only a short-step synthesis but is applicable to gram-scale synthesis of a protected (±)-aurantioclavine.