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Short Paper | Special issue | Vol 99, No. 2, 2019, pp.1315-1321
Published online, 17th December, 2018
DOI: 10.3987/COM-18-S(F)45
Palladium Acetate-Catalyzed One-Pot Synthesis of Mono- and Disubstitued Pyridines

Shunya Mikami and Masahiro Toyota*

*Department of Chemistry, Graduate School of Science, Osaka Prefecture University, 1-1 Gakuencho, Sakai, Osaka 599-8531, Japan


A Pd-catalyzed one-pot synthesis of mono- and disubstituted pyridines was developed. The substituted pyridines were obtained from ketones or an aldehyde and 1,3-diaminopropane using a combination of catalytic Pd(OAc)2 and Cu(OAc)2. High-concentration reaction conditions enabled this catalytic reaction to be acid-free.