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Paper | Special issue | Vol 99, No. 1, 2019, pp.171-187
Published online, 4th June, 2018
DOI: 10.3987/COM-18-S(F)6
Synthesis and Cytotoxicity of Novel Bis-Ellipticines and Bis-Isoellipticines

Judy A. Obaza-Nutaitis and Gordon W. Gribble*

*6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, U.S.A.

Abstract

A series of bis-ellipticines 79 and bis-isoellipticines 1012 tethered through the indole nitrogen was synthesized and screened for antitumor cytotoxicity in the L-1210 murine leukemia assay. Activity was only displayed by 1,10-bis(6-ellipticinyl)-n-decane (8).