Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Special issue | Vol 99, No. 2, 2019, pp.1330-1341
Published online, 16th November, 2018
DOI: 10.3987/COM-18-S(F)54
Bimetallic Lewis Acid Template-Mediated Enantioselective Hetero-Diels-Alder Reactions of 4-Siloxy-2,4-pentadienols

Jun Ishihara,* Yuka Ohzono, Kengo Oka, Yasuhiro Urayama, and Susumi Hatakeyama

*Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, 852-8521, Japan


Enantioselective hetero-Diels-Alder reactions catalyzed by a bimetallic Lewis acid template are described. The hetero-Diels-Alder reactions of 4-siloxy-2,4-pentadienols and various dienophiles by the chiral H8-BINOL template provide a general entry into the substituted dihydropyrans with good enantioselectivities. This protocol is also applicable to a dihydropirazine formation.