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Short Paper | Regular issue | Vol 96, No. 5, 2018, pp.931-942
Published online, 27th April, 2018
DOI: 10.3987/COM-18-13892
A New Phenolic Compound from Salix glandulosa

Chung Sub Kim, Lalita Subedi, Joonseok Oh, Sun Yeou Kim, Sang Un Choi, and Kang Ro Lee*

*Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea


A new phenolic compound, saliglandol (1), was isolated from Salix glandulosa along with 22 known ones. Their chemical structures were established through analyzing spectroscopic data. Comparison of calculated and experimental ECD spectra of 1 resulted in assignment of its absolute configuration. All isolated compounds (123) were evaluated for their cytotoxic activities against four human cancer cell lines (A549, SK-OV-3, SK-MEL-2, an BT549), anti-inflammatory effects measuring nitric oxide (NO) levels in lipopolysaccharide (LPS)-stimulated murine microglia BV2 cells, and potential neuroprotective effects through induction of nerve growth factor (NGF) in C6 glioma cells.