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Paper | Special issue | Vol 99, No. 1, 2019, pp.521-533
Published online, 26th December, 2018
DOI: 10.3987/COM-18-S(F)49
Identification of Target Protein for Batzelladines as CD4

Jun Shimokawa* and Kazuo Nagasawa*

*Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan

Abstract

Batzelladines are a family of polycyclic guanidine alkaloids. Among the congeners, batzelladines A-E were reported to inhibit the interaction of human immunodeficiency virus (HIV) gp120 protein with human CD4. Here, we designed a batzelladine photoaffinity probe bearing trifluoromethyl-3H-diazirine and biotin groups, and employed it to establish the identity of the target protein of batzelladines as CD4.