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■ Novel Antioxidant Isolated from Warcupiella spinulosa JCM 2358, 7-Hydroxycordylactam

Ryosuke Shigemoto, Ken-Ichi Oinuma, Shunsuke Masuo, and Naoki Takaya*

*Faculty of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8572, Japan

Abstract

We identified a new compound, 7-hydroxycordylactam, together with the known compound, cordylactam, from cultured Warcupiella spinulosa JCM 2358. Their structures were elucidated using high-resolution mass spectrometry and NMR spectroscopy. The spectra indicated that these compounds have a γ-lactam-fused γ-pyrone skeleton. Analysis of their antioxidant activities showed that both 7-hydroxycordylactam and cordylactam scavenged 1,1-diphenyl-2-picrylhydrazyl radicals with an IC50 of 340 µM.