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Paper | Special issue | Vol 99, No. 1, 2019, pp.534-548
Published online, 9th November, 2018
DOI: 10.3987/COM-18-S(F)51
Synthesis of Novel Resveratrol-Phthalide Hybrid Compounds and Evaluation of Their Inhibitory Activities of Nitric Oxide Production

Tetsutaro Kimachi,* Tokutaro Ogata, Misae Doe, Mariko Sakanaka, Arisa Nishiuchi, Mio Aomatsu, Manami Tanaka, Maki Shimizu, Natsuko Yoshioka, Kurumi Kubota, Yui Teraoka, Chikako Nakajima, and Satoru Takahashi*

*School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Koushien Kyuban-Cho, Nishinomiya, Hyogo 663-8179, Japan


Four types of novel resveratrol-phthalide hybrid compounds were designed and synthesized systematically by Suzuki-Miyaura cross-coupling reaction. These hybrid compounds were evaluated upon an inhibitory effect of the LPS-stimulated NO production in murine macrophage cell line, RAW264.7. As a result, two of them showed stronger inhibitory activity than the original resveratrol.