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Short Paper | Regular issue | Vol 96, No. 6, 2018, pp.1080-1087
Published online, 10th May, 2018
DOI: 10.3987/COM-18-13897
One-Pot Synthesis of Model 1H,1'H-5,5'-Bi(1,2,4-Triazoles)

Mustafa M. El-Abadelah, Monther S. Zreid, and Mohammed M. Abadleh*

*Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, University of Petra, Amman 11196, Jordan


Direct interaction of diaminomaleonitrile with model in situ generated nitrile imine 1,3-dipoles resulted in a direct synthesis of the corresponding 5,5'-bi(1,2,4-triazoles). A plausible mechanism is advanced for this new preparative route.