Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Special issue | Vol 99, No. 1, 2019, pp.649-660
Published online, 19th September, 2018
DOI: 10.3987/COM-18-S(F)25
Formal Synthesis of Gephyrotoxin 287C

Katsuki Takashima and Naoki Toyooka*

*Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan

Abstract

The enantioselective formal synthesis of (-)-gephyrotoxin 287C (1) has been achieved from octahydroquinolinone 8. The α, β-unsaturated ester 16, whose enantiomer was a key intermediate for the total synthesis of (+)-1, was synthesized by highly stereoselective Michael-type conjugate addition reaction to 8 and subsequent transformations.