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Communication | Special issue | Vol 101, No. 2, 2020, pp.407-416
Published online, 24th July, 2019
DOI: 10.3987/COM-19-S(F)22
One-Pot Synthesis of 9-Spirofluorenes via Tandem Copper-Catalyzed Arylative Cyclization and Spirocyclization of Biaryl-Substituted Alkynyl Alcohols

Noriko Okamoto, Takuya Sueda, and Reiko Yanada*

*Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1, Hirokoshingai, Kure, Hiroshima, 737-0112, Japan

Abstract

A tandem copper-catalyzed arylative cyclization and spirocyclization strategy to access spiro cyclic compounds is described. This method enables the one-pot construction of 9-spirofluorenes from readily available alkynyl alcohols with biaryl-substituents via the copper-catalyzed arylative ring-closing reaction and the Friedel–Crafts reaction.