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Short Paper | Special issue | Vol 101, No. 2, 2020, pp.707-716
Published online, 16th August, 2019
DOI: 10.3987/COM-19-S(F)43
Concise Synthesis of TPCA-1 and Related Thiophene-carboxamides by Cross Coupling

Norihiko Kawasaki, Hayato Fukuda, and Jun Ishihara*

*Pharmaceutical Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan

Abstract

A synthesis of 5-substituted 2-[(aminocarbonyl)amino]-3-thiophene- carboxamides is described. The coupling reaction of 2-ureidothiophene- 3-carboxamide and various aryl compounds allows the concise approach of promising candidates for IKK-2 inhibitor, such as TPCA-1