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Paper | Special issue | Vol 101, No. 2, 2020, pp.631-644
Published online, 9th October, 2019
DOI: 10.3987/COM-19-S(F)54
Ligand Assessment for the Suzuki-Miyaura Cross Coupling Reaction of Aryl and Heteroaryl Bromides with n-Butylboronic Acid. The Advantages of Buchwald’s S-Phos

Thomas Jagusch, Sven Nerdinger, Bernd Lehnemann, Stefan Scherer, Andreas Meudt, Victor Snieckus,* Sandro Neuner, and Herwig Schottenberger

*Department of Chemistry, Queen's University, 90 Bader Lane K7L 3N6, Canada

Abstract

An investigation of biarylphosphine ligands for the Suzuki-Miyaura cross coupling reaction of aryl and heteroaryl bromides with n-butylboronic acid is presented. The results obtained on ligand modification and aryl as well as heteroaryl bromides variation represent a significant improvement in the state of the art of alkylboronic acid cross coupling methodology.