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Short Paper | Regular issue | Vol 98, No. 12, 2019, pp.1747-1754
Published online, 26th December, 2019
DOI: 10.3987/COM-19-14188
Pentenyl Coumarins from the Roots and Stems of Yunnan Local Sun Cured Tobacco and Their Bioactivity

Qiu-Fen Hu,* Dian Luo, Na Lv, Yin-Ke Li, Wei-Song Kong, Jing Li, Xin Liu, Qian Gao, Guang-Yu Yang, Hai-Ying Xiang,* and Ju-Xing Jiang*

*Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, China

Abstract

Three new (1-3), together with two known (4 and 5) pentenyl coumarins were isolated from the roots and stems of Yunnan local sun cured tobacco. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1~5 were tested for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compound 2 showed strong inhibition with inhibition zone diameter (IZD) of 18.6 ±2.6 mm, and compounds 1, 3, 4, and 5 showed good inhibition with IZD of 14.2±2.2, 14.8±2.3, 12.4 ±2.2, and 15.1±1.8 mm, respectively. Compounds 1-5 were also tested for the antioxidant activity, and they showed notable antioxidant activity with IC50 values of 4.92, 4.18, 4.43, 4.65, and 4.07 μg/mL, respectively