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Short Paper | Regular issue | Vol 100, No. 2, 2020, pp.267-275
Published online, 4th February, 2020
DOI: 10.3987/COM-19-14198
Three New Furan-2-Carboxylic Acid Derivatives from the Stem Bark of Nicotiana tabacum and Their Bioactivity

Yin-Ke Li, Na Lv, Dian Luo, Wei-Song Kong, Qi-Li Mi, Qian Gao, Wan-Li Zeng, Jing Li, Jun Ling, Chun-Bo Liu, Guang-Yu Yang, Xue-Mei Li, Zhang-Yu Chen,* and Qiu-Fen Hu*

*Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650031, China


Three new (1-3), together with three known (4-6) furan-2-carboxylic acid derivatives were isolated from the stem bark of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1~6 were tested for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1-6 showed good inhibition with IZD of 12.8±2.3, 13.5±1.8, 14.3 ±2.2, 15.1 ±2.0, and 14.7±2.2 mm. Compounds 1-6 were also tested for the antioxidant activity, and they showed notable antioxidant activity with an IC50 value of 3.86, 4.05, 3.62, 4.11, 3.57, and 3.64 μg/mL, respectively.