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Paper | Regular issue | Vol 100, No. 4, 2020, pp.547-558
Published online, 5th March, 2020
DOI: 10.3987/COM-20-14201
Bis(1,3-dimethylimidazolidinone) Hydrotribromide (DITB) Promoted Multicomponent Reaction for the Synthesis of Highly Functionalized Piperidines

Shiqiang Yan, Shuwang He, Shuying Li, Zhiqiang Hu,* and Wei Zhang*

*School of Pharmacy, Fudan University, Shanghai 201203, China


A convenient and efficient method has been developed for the synthesis of highly functionalized piperidines via three-component, one-pot domino reaction of β-ketoesters, aromatic aldehydes, and anilines in the presence of catalytic amount of bis(1,3-dimethylimidazolidinone) hydrotribromide (DITB) in ethanol at room temperature.