Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 100, No. 4, 2020, pp.547-558
Published online, 5th March, 2020
DOI: 10.3987/COM-20-14201
Bis(1,3-dimethylimidazolidinone) Hydrotribromide (DITB) Promoted Multicomponent Reaction for the Synthesis of Highly Functionalized Piperidines

Shiqiang Yan, Shuwang He, Shuying Li, Zhiqiang Hu,* and Wei Zhang*

*School of Pharmacy, Fudan University, Shanghai 201203, China

Abstract

A convenient and efficient method has been developed for the synthesis of highly functionalized piperidines via three-component, one-pot domino reaction of β-ketoesters, aromatic aldehydes, and anilines in the presence of catalytic amount of bis(1,3-dimethylimidazolidinone) hydrotribromide (DITB) in ethanol at room temperature.