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Short Paper | Regular issue | Vol 100, No. 2, 2020, pp.283-292
Published online, 17th February, 2020
DOI: 10.3987/COM-20-14222
Synthesis and Cytotoxic Activity of Some New Bipyrazole Derivatives

Bader A. Salameh,* Kayed A. Abu-Safieh,* Islam S. AL-Aqrabawi, Fatima Alsoubani, and Lubna H. Tahtamouni

*Department of Chemistry, Faculty of Science, Hashemite University, P.O. Box 330127 Zarqa, 13133, Jordan


A new series of bipyrazole derivatives were prepared and characterized via the reaction of 5-hydrazino-1,3-dimethyl-4-nitro-1H-pyrazole with various 1,3-dicarbonyl compounds. The synthetic pathway was based on the classical Knorr pyrazole synthesis. In vitro cytotoxic activity of the fully characterized bipyrazole derivatives was determined and their IC50 values were also reported.