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Short Paper | Regular issue | Vol 100, No. 4, 2020, pp.645-652
Published online, 23rd March, 2020
DOI: 10.3987/COM-20-14229
Antifungal Compound against Azole-Resistant Candida albicans from a Marine-Derived Fungus, Paraboeremia selaginellae

Eri Yamaguchi, Kazuha Okabe, Hitoshi Kamauchi, Sanae Kurakado, Takashi Sugita, Kaoru Kinoshita,* and Kiyotaka Koyama*

*Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

A new compound (1) and AB4063-A (2), whose stereochemistry was unstated, were isolated from the marine-derived fungus Paraboeremia selaginellae. The structure of 1 was elucidated from spectroscopic data (NMR, MS, IR), and the absolute configuration of the N-methylvaline moiety was determined. Compound 2 showed antifungal activity against azole-resistant Candida albicans.