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Short Paper | Regular issue | Vol 100, No. 5, 2020, pp.803-808
Published online, 25th March, 2020
DOI: 10.3987/COM-20-14231
Synthesis of Methylophiopogonanone A

Ryo Katagiri, Yoshinori Uekusa, Yuji Narukawa, and Fumiyuki Kiuchi*

*Faculty of Pharmacy, Keio University, 1-5-30 Shiba-Kouen, Minato-ku, Tokyo, Japan

Abstract

Ophiopogon Root (root of Ophiopogon japonicus Ker-Gawler, Liliaceae) is a crude drug used as expectorant, anti-cough and tonic in Kampo medicine (traditional Japanese medicine) as well as other traditional medicines of Asian countries. It contains characteristic homoisoflavonoids with methylated ring A. We synthesized methylophiopogonanone A (1), which is a candidate marker compound for identification test of Ophiopogon Root, from phloroglucinol in 9 steps with overall yield of 11.1%