Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 100, No. 8, 2020, pp.1218-1232
Published online, 3rd July, 2020
DOI: 10.3987/COM-20-14276
Efficient Synthesis of 2-Functionalized Benzoxazoles Catalyzed by Copper Iodide

Han Cao,* Xue-Jing Liu,* Fu-sheng Bie, Peng Yan, Jie Ma, Yi-jun Shi, and Ying Han

*Engineering and Technology Research Institute of Lunan Coal Chemical,, Zaozhuang University, 1 Beian Road, China

Abstract

We reported an efficient synthesis of 2-functionalized benzoxazoles in mild condition and excellent yields. The synthetic process includes two steps. The step one contains a reaction of pendent halide formamidine derivatives and 2- aryloxyacetyl chloride generating highly selective (Z)-N-(2-halophenyl)-3-(dime- thyllamino)-2-aryloxyacrylamides, and the step two undergoes copper iodide catalyzed intramolecular C-O bond formation to yield title compounds. This strategy is not only providing newly discovered key intermediates 6a-l which contain multiple functional groups on 2-position (as building blocks), but also expanded the scope of methodologies for making diverse benzoxazoles with multiple functional groups.