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Paper | Regular issue | Vol 100, No. 8, 2020, pp.1233-1247
Published online, 18th June, 2020
DOI: 10.3987/COM-20-14282
Synthesis and Biological Evaluation of New Curcumin Analogs Inhibiting Osteoclastogenesis

Aoi Sugawara, Toshika Ohashi, Satoshi Ogawa, Naomi Matsumoto, Mayumi Nakanishi-Matsui, Satoru Tamura, and Tomikazu Kawano*

*School of Pharmacy, Iwate Medical University, 1-1-1 Idaidori, Yahaba , Iwate, Japan

Abstract

A series of curcumin analogs (1-3) were newly designed and synthesized for the development of therapeutic agents for osteoporosis. Among the synthesized compounds, 2,5-substituted conjugated thiophene derivative (1a) and the corresponding pyrazine derivative (1c) were shown to be potential leads for the development of anti-osteoclastogenesis agent.