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Review | Special issue | Vol 103, No. 1, 2021, pp.129-143
Published online, 19th January, 2021
DOI: 10.3987/REV-20-SR(K)4
Lesinurad – There are More Ways than One of Synthesizing the Drug

Piotr P. Graczyk* and Sven Nerdinger*

*Early Stage Development, Sandoz GmbH, Biochemiestrasse 10, 6250 Kundl, Austria


Over the last several years significant efforts have been devoted, particularly in China, to develop new syntheses of Lesinurad. Virtually all key bonds in this molecule can now be created in many different ways, often in a very high yield. Although almost all of the chemistry examples presented in this review come from patent applications and as such have not been subjected to rigorous peer review, they may serve as an inspiration to solve analogous synthetic problems. However, the readers are encouraged to pay particular attention to the very recent trends in the literature which use multicomponent reactions and flow chemistry to minimize the environmental impact and achieve high yields of API at the same time.