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Short Paper | Regular issue | Vol 100, No. 8, 2020, pp.1260-1267
Published online, 3rd July, 2020
DOI: 10.3987/COM-20-14296
Three New Benzazepine Alkaloids from Thalictrum cirrhosum and Their Anti-Rotavirus Activity

Qiu-Fen Hu, Dian Luo, Na Lv, Ya-Ning Zhu, Lu Liu, Fan Wu, Dong Miao, Wei-Guang Wang, Qian Gao, Min Zhou,* and Guang-Yu Yang*

*Technical center, China Tobacco Yunnan Industrial Co., Ltd., Keyi Road 41#, China

Abstract

Three new benzazepine alkaloids, cirrhobenzazepines A-C (1-3), together with four known alkaloids (4-7) were isolated from the whole plants of Thalictrum cirrhosum. Their structures were elucidated by spectroscopic methods, including extensive 1H, 13C, and 2D-NMR techniques. Compounds 1-7 were tested for their anti-rotavirus activity. The results revealed that compounds 1-7 exhibited potent anti-rotavirus activity with TI valves in the range of 11.9-18.2, respectively.