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Short Paper | Regular issue | Vol 100, No. 10, 2020, pp.1686-1693
Published online, 7th August, 2020
DOI: 10.3987/COM-20-14320
Ukixanthomycin A: A Hexacyclic Xanthone from the Mudflat-Derived Actinomycete Streptomyces sp.

Yuhei Koyanagi, Teppei Kawahara, Yuki Hitora, and Sachiko Tsukamoto*

*Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan


A new hexacyclic xanthone, ukixanthomycin A (1), was isolated from the mudflat-derived Streptomyces sp. HGMA004 by screening based on chemical analysis by UPLC-HRMS with our in-house actinomycete extract library. The structure of 1 was elucidated by spectral analyses and quantum chemical calculations. Compound 1 showed weak antifungal activity against Candida albicans.