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Short Paper | Regular issue | Vol 102, No. 2, 2021, pp.291-317
Published online, 23rd December, 2020
DOI: 10.3987/COM-20-14354
Synthesis and Biological Studies of Some New Pyrazole, Dihydropyridinethione, Pyrimidine, Thiophene and 4H-Pyran Derivatives

Ibrahim Saad Abdel Hafiz, Mohamed Ahmed Mahmoud Abdel Reheim,* Hala Mohamed Reffat, and Ahmed Adel Mohamed Sarhan

*Department of Chemistry, Faculty of Science, Arish Univeristy, Arish 45511, Egypt

Abstract

This study aims to synthesis of 1-(2-hydroxy-4-methylphenyl)-3-phenylpropane-1,3-dione 3 in a quantitative yield from the reaction of ethyl benzoylacetate and m-cresol using a microwave in the absence of solvents. Phenylpropane-1,3-dione derivative 3 was used as the key synthetic intermediate for the synthesis of many derivatives in this study. A new pyrazole 12, pyrimidine 15, thiophene 37, 4H-pyrane 51 and pyridine derivatives 8, 28, 34, 41 and 46 were synthesized through different chemical reactions. The structures of the newly synthesized compounds were confirmed based on analytical and spectral data. The compounds were evaluated for both their in vitro antibacterial and antifungal activities. The compounds showed varying degree of antimicrobial activity.