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Short Paper | Regular issue | Vol 102, No. 2, 2021, pp.325-332
Published online, 15th December, 2020
DOI: 10.3987/COM-20-14373
Peniphilones A and B: Azaphilone Alkaloids from the Endophytic Fungus Penicillium maximae

Yuhei Koyanagi, Yuki Hitora, Teppei Kawahara, and Sachiko Tsukamoto*

*Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-hon-machi, Kumamoto 862-0973, Japan


Two new azaphilone alkaloids, peniphilones A and B (1 and 2), and a known congener, (+)-sclerotiorin (3), were isolated from the endophytic fungus Penicillium maximae by screening based on chemical analysis by UPLC-HRMS with our in-house extract library of natural sources. The structures of 1 and 2 were elucidated on the basis of NMR and HRESI-MS spectroscopic data.