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Short Paper | Regular issue | Vol 102, No. 3, 2021, pp.481-488
Published online, 28th January, 2021
DOI: 10.3987/COM-20-14382
DBU-Catalyzed Highly Efficient Synthesis of 1,4-Dihydropyridine Derivatives from Arylidenemalononitriles and β-Enamino Imides

Wei Han, Kazuya Nakajima, Masashi Kajitani, and Takeshi Oriyama*

*Department of Chemistry, Faculty of Science, Ibaraki University, 2-1-1 Bunkyo, Mito, Ibaraki 310-8512, Japan


Various 1,4-dihydropyridine derivatives were efficiently synthesized from arylidenemalononitriles and β-enamino imides using DBU (3 mol%) as the catalyst at room temperature. This mild, straightforward high-yielding protocol was atom-economy, time-economy, with a low catalyst load, and without the need for reflux.