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Communication | Special issue | Vol 103, No. 2, 2021, pp.694-698
Published online, 12th January, 2021
DOI: 10.3987/COM-20-S(K)66
Facile Preparation of 1-Hydroxy-1,2-Benziodoxol-3(1h)-one 1-Oxide (IBX) and Dess–Martin Reagent Using Sodium Hypochlorite under Carbon Dioxide

Kazunori Miyamoto,* Tomohide Okada, Takashi Toyama, Shinji Imamura, and Masanobu Uchiyama*

*Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan


We have developed a safe, convenient, and inexpensive method for preparation of the widely used oxidizing agent 1-hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide (IBX), by treatment of 2-iodobenzoic acid with aqueous sodium hypochlorite under CO2 at room temperature. As the only by-product is NaCl, this reaction can be utilized for one-pot synthesis of 1,1,1-triacetoxy-1,2-benziodoxol-3(1H)-one (Dess-Martin reagent) in excellent yield.