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Paper | Regular issue | Vol 102, No. 3, 2021, pp.465-479
Published online, 28th January, 2021
DOI: 10.3987/COM-20-14383
Efficient Approach towards the Polysubstituted 4H-Pyran Hybrid Quinolone Derivatives and Subsequent Copper-Catalyzed Hydroxylation of Haloarenes

Vipin Kumar, Dharmender Singh, Raghuram Gujjarappa, Chandi C. Malakar,* and Virender Singh*

*Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal-795004, Manipur, India


A proficient and feasible approach towards polysubstituted quinolone conjugated 4H-pyrans has been elucidated. The illustrated phenomenon concern with the base-mediated multicomponent reaction and subsequent copper-catalyzed hydroxylation of C-X bond emerging in an amide functionality. The developed reaction conditions showcased considerable substrate scope and functional group tolerance by giving the desired products in good yields.