Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 102, No. 2, 2021, pp.245-253
Published online, 24th December, 2020
DOI: 10.3987/COM-20-14386
Synthesis of Roche Lactone via the Enantioselective Alcoholysis of meso-Cyclic Anhydride Strategy: A Practical Approach Employing an Efficient and Reusable Organic Microgel Auxiliaries

Fei Xiong,* Chang-Cheng Xi, Chao Ma, Lu Chen, Ming-Wei Sun, Xing-Guang Zhang, and Dan-Feng Hong

*Department of Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China

Abstract

Roche lactone, a key chiral intermediate of the natural water-soluble B series vitamin (+)-biotin, was synthesized from meso-cyclic anhydride in overall yield 78% through three steps, including heterogeneous asymmetric desymmetrization, chemoselective reduction and lactonization.