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Short Paper | Regular issue | Vol 102, No. 3, 2021, pp.506-515
Published online, 27th January, 2021
DOI: 10.3987/COM-20-14394
Synthesis and in vitro Biological Evaluation of Cananodine

Abdullah Yusuf,* Paruke Aibibula, Ju-Bao Zhang, Guo-Zheng Huang, Haji Akber Aisa, and Jiang-Yu Zhao*

*College of Chemistry and Environmental Science, Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, Kashgar University, Xueyuan Road 29, Kashgar 844000, P. R. China


(±)-Cananodine was obtained by common reactions from (±)-rupestine G and was isolated and synthesized by our group. (+)-Cananodine and its enantiomer were obtained by chiral separation and their absolute configurations were determined by high-resolution mass spectrometry, nuclear magnetic resonance, and electronic circular dichroism spectroscopy. The optical rotation of both cananodine and its enantiomer were re-treated. Biological activity against Hep G2, Hela, and MDA-MB-231 were also investigated.