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Paper | Regular issue | Vol 102, No. 5, 2021, pp.920-929
Published online, 9th March, 2021
DOI: 10.3987/COM-21-14424
Synthesis and Cytotoxicity Properties of Some Novel Functionalized 2-{2-[(4-Oxo-4H-chromen-3-yl)methylene]hydrazinyl}-1,3-selenazoles

Tarik E. Ali,* Mohammed A. Assiri, and Hanaa R. Aboelwafa

*Department of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi Arabia


A series of novel functionalized 1,3-selenazoles bearing 4-oxo-4H-chromen-3-yl moiety was constructed by Hantzsch-type condensation reaction. The methodology depended on the cyclization of N-[(4-oxo-4H-chromen-3-yl)methylene]selenosemicarbazide with bis-halogen and α-halocarbonyl compounds in DMF. The structures of the synthesized compounds were assigned based on the spectral tools. The cytotoxicity properties of the products were evaluated. Both compounds 9 and 11 showed significant cytotoxic properties against HCT-116, Hep-G2, A-549 and MCF-7 cancer cell lines.