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Communication | Regular issue | Vol 102, No. 10, 2021, pp.1939-1947
Published online, 27th July, 2021
DOI: 10.3987/COM-21-14502
A Long-Wavelength Emission Fiuorescent Probe Based on TCF Derivatives for High-Sensitivity Detection of Hg2+

Yuan Sun, Keli Zhong, Lijun Tang,* and Xiaomei Yan*

*College of Chemistry and Materials Engineering, Bohai University, Jinzhou, 121013, China


A new fluorescent probe 1 that derived from 2-dicyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran (TCF) has been developed. Probe 1 displays selective recognition toward Hg2+ in MeOH/Tris (1:1, v/v, Tris 20 mM, pH = 7.4) solution through fluorescence turn on behavior. The Hg2+ sensing mechanism underwent Hg2+-triggered removal of thiocarbonyl moiety of probe 1, which resulting in releasing of the highly emissive compound 2. The Hg2+ recognition process holds some advantages including rapid response (<3 min), low detection limit (1.06 nM), and a large Stokes shift (160 nm). Cell imaging studies showed that probe 1 has membrane permeability and low toxicity to cells, and can be used to detect Hg2+ in living cells.