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Short Paper | Regular issue | Vol 102, No. 8, 2021, pp.1563-1569
Published online, 27th May, 2021
DOI: 10.3987/COM-21-14479
Multicomponent Reaction for the Synthesis of 1,2,3,4,6-Pentasubstituted Piperidines Catalyzed by NIS

Liu Pengpeng*

*School of Petroleum and Chemical Engineering, Dongying Vocational Institute, Dongying, 257091, China


An efficient, suitable and high yielding method has been developed for the synthesis of substituted piperidines via multicomponent, one-pot domino reaction of β-keto ester, aromatic amines, and aromatic aldehydes in the presence of catalytic amount of N-iodosuccinimide (NIS) in ethanol. Atom economy, mild reaction conditions, good to excellent yields, operational simplicity and easy work-up are some of the important features of this method.