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Short Paper | Regular issue | Vol 102, No. 8, 2021, pp.1570-1578
Published online, 14th May, 2021
DOI: 10.3987/COM-21-14480
■ Total Synthesis of Hyalodendriol C

Ishtiaq Jeelani,* Katsunori Itaya, and Hitoshi Abe

*Graduate School of Innovative Life Science, University of Toyama, 3190 Gofuku 930-8555, Japan

Abstract

We present a total synthesis of hyalodendriol C, a fungal natural product. We have focused on the use of palladium-catalyzed intramolecular biaryl coupling reaction of phenyl benzoate derivatives to synthesize hyalodendriol C. Keeping in view, the indispensable biological values of this compound, we took the advantage of our established strategy to chemically synthesize hyalodendriol C. The total synthesis of hyalodendriol C got accomplished in 10 steps beginning with the preparation of phenol derivative from the commercially available 5-methylbenzene-1,3-diol and synthesis of the corresponding benzoic acid derivative.