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Short Paper | Regular issue | Vol 102, No. 8, 2021, pp.1588-1594
Published online, 17th June, 2021
DOI: 10.3987/COM-21-14484
Three New Anti-Rotavirus Quinoline Alkaloids from the Whole Plant of Thalictrum glandulosissimum

Qiu-Fen Hu, Fan Wu, Ya-Ning Zhu, Lu Liu, Ming-Xin Liu, Bing-Biao Cai, Man-Fei Li, Dong Miao, Min Zhou,* and Guang-Yu Yang*

*Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Minzu University, Kunming 60500, P. R. China

Abstract

Three new quinoline alkaloids, 4-acetyl-6-methyl-7-(3-methyl-2-oxobut-3-enyl)quinolin-2(1H)-one (1), 4-acetyl-5-methyl-7-(3-methyl-2-oxobut-3-enyl)quinolin-2(1H)-one (2), and 4-acetyl-6-methyl-7-prenylquinolin-2(1H)-one (3) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were elucidated by spectroscopic methods, including extensive 1H, 13C, and 2D-NMR techniques. Compounds 1-3 were also tested for their anti-rotavirus activity. Compounds 1-3 exhibited potent anti-rotavirus activity with therapeutic index (TI) valves of 17.6, 15.0, and 23.6 respectively.