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Paper | Regular issue | Vol 102, No. 10, 2021, pp.1982-1994
Published online, 19th July, 2021
DOI: 10.3987/COM-21-14512
A Facile, Efficient and Catalyst Free Synthesis of Imidazole, Tetrazole and Pyrimidine Combined Moiety as Potential Antimicrobial and Antitubercular Agents

Nayankumar M. Panchani and Hitendrakumar S. Joshi*

*Department of Chemistry, Saurashtra University, Saurashtra University, Rajkot-360 005, India

Abstract

The tetrazole fused pyrimidine system possesses a broad spectrum of biological activities. So, we have synthesized 5-(substitutedphenyl)-7-(1H- imidazol-4-yl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine derivatives (5a-n) by reaction of chalcones with 5-aminotetrazole without catalyst in appropriate solvent. The structural elucidation of these compounds is based on MS, IR, 1H-NMR and 13C-NMR spectral data. The in vitro anti-microbial activity was investigated against Gram-positive and Gram-negative bacterial and fungal strains. It was found that the compounds 5a, 5b, 5c, 5d, 5e showed significant activities against tested organisms as compared to standard drugs (Ampicillin and Griseofulvin) while compounds 5a, 5c, 5i, and 5k showed good percentage of average inhibition in the dormant and active stage of tuberculosis.