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Short Paper | Regular issue | Vol 102, No. 11, 2021, pp.2190-2196
Published online, 2nd September, 2021
DOI: 10.3987/COM-21-14521
Quinoline Alkaloids from the Leaves of Cigar Tobacco and Their Anti-Tobacco Mosaic Virus Activity

Guang-Hui Kong, Guang-Hai Zhang, Zhong-Long Lin, Gao-Kun Zhao, Yin-Ke Li, Heng Yao, Guang-Yu Yang, Qiu-Fen Hu,* and Yu-Ping Wu*

*Yunnan Academy of Tobacco Agricultural Sciences, Kunming, Yunnan 650031, P. R. China

Abstract

Three new (1-3), together with three known (4-6) quinoline alkaloids were isolated from the leaves of cigar tobacco (a variety of Nicotiana tabacum). Their structures were elucidated by spectroscopic methods, including extensive 1H, 13C, and 2D-NMR techniques. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that compound 3 exhibited high anti-TMV activity with inhibition rate of 42.2% at the concentration of 20 μM. This rate in higher than that of positive control (with inhibition rate of 32.5% at the concentration of 20 μM). Compounds 1, 2, 4~6 also showed potential anti-TMV activity with inhibition rates of 28.2, 31.0, 22.8, 26.6, and 29.5% at the concentration of 20 μM, respectively. These rates are slightly lower than that of positive control.