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Review | Regular issue | Vol 104, No. 2, 2022, pp.229-266
Published online, 18th October, 2021
DOI: 10.3987/REV-21-970
Click Chemistry toward the Synthesis of Anticancer Agents

Ashutosh Pal* and Bimal Krishna Banik*

*Department of Chemistry, Raja Peary Mohan College, West Bengal, India


The copper(I)-induced synthesis of 1,2,3-triazoles using azides and alkynes (click chemistry) has become extremely significant. Click chemistry has been used in all aspects of drug discovery research. The product triazole serves as a linker as it readily combines with targets through hydrogen-bonding and dipole interaction. This review summarizes the application of click chemistry and triazoles as anticancer drugs. These types of reactions proceed with high selectivity, specificity, and yields. A variety of complex molecules are synthesized by this method.