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Paper | Regular issue | Vol 102, No. 11, 2021, pp.2168-2178
Published online, 7th September, 2021
DOI: 10.3987/COM-21-14541
Detection of New 3,4-Dimethylpyrrole Derivatives upon the Incubation of Exogenous Amines with Extract of Onion (Allium cepa) and Crude Alliinase from Garlic (A. sativum)

Taichi Yoneda, Seikou Nakamura,* Shogo Okui, Sayaka Okazaki, Souichi Nakashima, and Hisashi Matsuda

*Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan


Seven new N-substituted 3,4-dimethylpyrroles were obtained in situ through the reaction of an amine ((L)-phenylalanine, (L)-tryptophan, (L)-leucine, (L)-methionine, 1-phenethylamine, aniline or dodecylamine) and a mixture of unstable sulfur-containing compounds derived from the reaction of amino acids in Allium cepa and plant enzyme alliinase. In addition, a plausible reaction mechanism for the synthesis of N-substituted 3,4-dimethylpyrroles was displayed.