Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 104, No. 10, 2022, pp.1792-1808
Published online, 24th August, 2022
DOI: 10.3987/COM-22-14722
Ruthenium(II)-Catalyzed ortho Hydroxymethylation of 6-Arylpurines with Paraformaldehyde via Purine-Directed C-H Activation

Jiaqi Jiang, Junli Yang, Siqi Li, Yaxi Yang,* and Bing Zhou*

*State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China


A Ru-catalyzed ortho C-H hydroxymethylation of 6-arylpurines has been developed. A wide range of functional groups were tolerated, providing the hydroxymethylated products in good or excellent yields using the readily available paraformaldehyde as a C1 synthon. Moreover, this protocol could be carried out in the presence of water and air, without stoichiometric undesirable waste under mild reaction conditions.