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Review | Regular issue | Vol 106, No. 4, 2023, pp.594-639
Published online, 2nd February, 2023
DOI: 10.3987/REV-23-1002
Utility of 6-Aminouracils for Building Substituted and Heteroannulated Pyrimidines: A Comprehensive Review

Magdy A. Ibrahim, Zeinab Hussain,* Nasser M. El-Gohary, Yassin A. Gabr, Hassan A. Allimony, and Al-Shimaa Badran

*Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo-Egypt


6-Aminouracils are very useful intermediates for building different categories of heterocyclic compounds. 6-Aminouracils are electron rich compounds due to the presence of free amino group which can initiate interactions with electron deficient centres or activate the nearby C-5 position to start the reaction followed by cyclization in most cases. The present review summarizes the different reactions developed for the synthesis of substituted and annulated pyrimidines. A diversity of substituted pyrimidines was prepared directly from reactions of 6-aminouracils with some electrophilic reagents, meanwhile formation of fused pyrimidines were
achieved by reaction of 6-aminouracils with a variety of reagents such as aromatic and aliphatic aldehydes, acyclic and cyclic methylene ketones, cyclic enols, alkynes, iminium salts and a diversity of other reagents.