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■ A Convenient Synthesis of 5-Trifluoromethyl-5-cyclopropyl-Substituted Pyrazolines

Yong-Bin Xie, Xiao-Dong Liu, Ming-Xu Zhang, Wen-Bo Chen,* Chun-Hui Xing,* and Long Lu*

*CAS Key Laboratory of Energy Regulation Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, 200032 Shanghai, China

Abstract

A new method for the preparation of 5-trifluoromethyl-5-cyclopropylpyrazoline derivatives via cesium hydroxide mediated condensation reaction of ꞵ-trifluoromethyl-ꞵ-cyclopropyl-substituted unsaturated ketones with hydrazines was reported. The approach featuring mild reaction conditions, broad substrates scope and good functional group tolerance, provided a strategy to synthesize new functionalized pyrazolines bearing both trifluoromethyl and cyclopropyl groups.