Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 106, No. 5, 2023, pp.847-857
Published online, 14th March, 2023
DOI: 10.3987/COM-23-14830
Transnitrosation of Alicyclic N-Nitrosamines Containing Sulfur Atoms in Five- or Six-Membered Rings

Noriko Usui, Masataka Mochizuki, and Keiko Inami*

*Division of Pharmaceutical Organic Chemistry, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Daigakudo-ri 1-1-1, Sanyo-onoda-shi,Yamaguchi, Japan

Abstract

Nitric oxide (NO) is a cell transmitter produced in vivo. Alicyclic N-nitroso compounds serve as potential NO donors in vivo due to the formation of S-nitrosoglutathione by transnitrosation. In this study, N-nitroso compounds with a thioamide group and endocyclic sulfur atoms in 5- or 6-membered rings were synthesized and the transfer of nitroso group was analyzed. All compounds synthesized exhibited transnitrosation activity under acidic condtions. N-Nitroso-1,3-thiazinane-4-carbothioamide exhibited the highest transnitrosation activity.